However, TL1A transgenic mice [26, 27], and Th17-mediated autoimmune disease model mice, experimental autoimmune encephalomyelitis [13] and dextran-sulfate-induced chronic colitis [32], show that TL1A-DR3 interaction could positively regulate Th17 cell function in vivo. Further research will be required to elucidate the regulatory mechanism of TL1A-DR3 interaction for Th17 cell function in vitro and in vivo. This evidence concerns the gene TNFSF15 and Chronic colitis.