Studies have shown that in DR3-deficient mice, or following blockade of TL1A-DR3 interaction by TL1A neutralization antibodies, OVA-induced lung inflammation is attenuated and Th2 cytokines IL-4, -5, and -13 production is reduced in a mouse model of asthma [10, 24]. The gene discussed is TNFRSF25; the disease is asthma.