CD4 and allergic rhinitis: While little information on the relationship between CD25+ T cells and TNF is available, a study which found that the percentage of CD4(+)CD25(+) T cells were significantly high, but the percentage of FoxP3(+) cells were low in allergic rhinitis patients, and that IL-4, IL-5, and TNF levels in nasal lavage fluids were high indicates that the increased TNF release may be from CD4(+)CD25(+), nonregulatory T cells [23].