Nonetheless, it might be due to increased myocardial responsiveness to calcium ion,19 increased sympathetic activity,26 increased plasma levels of Ang-(1-7)27 (believed to be a potent anti-ischemic and cardioprotective agent),8 or increased angiogensis.28 Decreased infarct size and CK-MB concentration in the coronary effluent in the renal hypertensive group is in agreement with increased angiogenesis in this model. This evidence concerns the gene ANG and renal hypertension.