Only in children who gained an IgG Ab response after the acute malaria episode, we observed a weak positive correlation between the percentage of IL-10–producing CD4+ T cells at acute disease and induction of DBLα-tag specific Ab responses to the homologous DBLα-tag (Spearman rho = 0.579, p = 0.0118) but not with other cytokine-producing CD4+ T cells. Here, CD4 is linked to malaria.