MED1 and Familial prostate cancer: The prognostic value of miRNA expression profiling in prostate cancer has also been demonstrated by Hulf et al. They demonstrated that DNA methylation and histone H3K9-deacetylation of the miR-205 locus is associated with miRNA silencing and deregulation of MED1, which is predictive of a poor prognosis in localized prostate cancer (49).