The highly significant correlation between miR-146a levels and IFN score in the return visits was unexpected, as the level of miR-146a in SLE was not significantly different from HD (Figures 1H and2H) and also it was previously reported to be decreased in SLE and inversely correlated with IFN score in a Chinese SLE cohort[46]. Here, IFNA1 is linked to systemic lupus erythematosus.