Even though ADAR expression was reported to be STAT1-independent[62,63], patient visits with low-STAT1 SLE (red, r2 = 0.29, P <0.0001), high-STAT1 SLE (blue, r2 = 0.35, P = 0.0002) patients, and low-STAT1 HD (black, r2 = 0.24, P <0.0001) displayed significant association between ADAR and IFN score (Figure 7A). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.