FOXO1 and neoplasm: Furthermore, many structurally uncharacterized Ets domain interactions involve other TFs central to cellular development or neoplasia, such as the androgen receptor [54], HOX homeodomains [55] and forkhead TFs, although an ETS1–FOXO1 (forkhead box O1) structure (PDB code 4LG0) is currently on hold in the PDB.