In addition, the most frequently represented InterPro domains were “Protein kinase, core,” “TGF-beta receptor/activin receptor, type I/II,” “Short-chain dehydrogenase/reductase SDR,” “MAD homology, MH1,” “SMAD domain-like,” and “SMAD domain, Dwarfin-type.” These results highlight the fundamental roles that signaling transduction of PAH-related genes play in controlling cell proliferation (Table S3, ESI†). This evidence concerns the gene CAVIN2 and pulmonary arterial hypertension.