VEGFB and cardiac hypertrophy: On the other hand, an overdose of VEGF-B via adenoviral delivery into the myocardium transiently enlarged myocardial vessels (Lahteenvuo et al, 2009; Serpi et al, 2011), and ameliorated angiotensin II-induced diastolic dysfunction (Serpi et al, 2011), while transgenic (TG) overexpression of VEGF-B in the rat myocardium induced cardiac hypertrophy and growth of the epicardial and subendocardial coronary vessels (Bry et al, 2010).