BRCA1 and ovarian cancer: Multivariate Cox regression analysis indicated that histological grade (Table 2, P = 0.001), pT (Table 2, P = 0.018), pM (Table 2, P = 0.001) and p53 status (Table 2, P = 0.007) were independent prognostic factors for predicting the overall survival of BRCA1-mutated ovarian cancer patients.