An inflammatory condition (i.e. NCAM1) or vascular insufficiency (e.g. HBB) and a decline in the energy metabolism (i.e. ATP5A1) are accompanied by the up-ward trend for anti-inflammatory (i.e. ICAM5), anti-apoptotic protein (i.e. PEA15) or proteins related to iron storage (i.e. FTL, FTH1) or anti-oxidative function (i.e. SOD1) (Fig. 4). Here, ATP5F1A is linked to vascular insufficiency disorder.