As depicted in Table 2, genes with a well-established role in cancer were down-regulated following GATA2 gene silencing, including FOXM1, c-MYC, UHRF1, EZH2, BMP6, AURKA, and BIRC5. The down-regulation of some of these genes was validated using qRT-PCR or Western blot analysis (Fig. 5A, B). The gene discussed is EZH2; the disease is cancer.