It is of interest that the genes whose expressions were altered by GATA2 silencing included FOXM1, BMP6, c-MYC, EZH2, BIRC5 and UHRF1 (Table 2), i.e. genes reported to have a role in prostate cancer progression and metastasis, suggesting that they represent downstream genes activated by GATA2 in the development of prostate cancer metastasis. This evidence concerns the gene BIRC5 and Familial prostate cancer.