It is of interest that the genes whose expressions were altered by GATA2 silencing included FOXM1, BMP6, c-MYC, EZH2, BIRC5 and UHRF1 (Table 2), i.e. genes reported to have a role in prostate cancer progression and metastasis, suggesting that they represent downstream genes activated by GATA2 in the development of prostate cancer metastasis. The gene discussed is BIRC5; the disease is prostate cancer.