CX3CR1 and early-onset autosomal dominant Alzheimer disease: Using this animal model, studies on lateral amyotrophic sclerosis [12], Parkinson’s disease [13], and Alzheimer’s disease [14] report that the absence of CX3CR1 is associated with a worse outcome possibly due to the lack of fractalkine control of microglial activation leading to chronic proinflammatory function [15].