RUNX3 and gastric cancer: 35 also found that RUNX3 reversed the EMT in hepatocellular carcinoma, but the mechanism underlying RUNX3 action is different in gastric cancer cells. Tanaka et al. 35 showed that ectopic RUNX3 protein expression induced E-cadherin expression and suppressed vimentin expression in hepatocellular carcinoma cells with low EMT.