Patients with a tumor that expressed either high p-mTOR or positive p-ERK1/2 protein did not benefit from tamoxifen (adjusted HR = 1.00, 95% CI = 0.48 to 2.08, P = 1.00), while patients whose tumor was negative for these two markers did derive significant benefit (adjusted HR = 0.25, 95% CI = 0.13 to 0.48, P < 0.0001) (P for interaction = 0.004) (Figure 1B; Table S16 in Additional file 1). Here, MTOR is linked to neoplasm.