RPS6KB1 and neoplasm: Patients whose tumor did not express p-p70S6K derived significant benefit from tamoxifen (HR = 0.24, 95% CI = 0.12 to 0.47, P < 0.0001), while patients whose tumor did express p-p70S6K had no benefit (multivariate HR = 1.02, 95% CI = 0.48 to 2.21, P = 0.95) (Figure 1A; Table S7 in Additional file 1).