In similar generalised linear regression models (Table 3) the PPARG allele C (Pro12) increased 2 hour insulin levels in the overall cohort (p = 0.009) and in the non-diabetic group only (p = 0.0003) after stratification by type 2 diabetes status, with a significant statistical interaction (p = 0.017). This evidence concerns the gene PPARG and type 2 diabetes mellitus.