These considerations suggest that by virtue of binding to MUC16, Meso-TR3 may also saturate and therefore reduce/eliminate the available binding sites on MUC16 for adhesive interactions with mesothelin-expressing normal endothelium, thus limiting the peritoneal dissemination of tumor cells in addition to augmenting TRAIL-mediated target cell death [36]. This evidence concerns the gene MUC16 and neoplasm.