MUC16 and neoplasm: Under the assumption that the mesothelin epitope of Meso-TR3 would not impact the killing capacity of the MUC16-targeted TRAIL fusion protein, we established the killing curves for TR3, Meso-TR3 and recombinant TRAIL (rTRAIL) and identified conditions under which all TRAIL drugs induced cell death to the same degree in the absence of the tumor marker MUC16 (Figure 3A).