Our results indicate that addition of mesothelin to the TR3 domain as in Meso-TR3, increases the effectiveness of TR3 in MUC16-positive malignancies such as ovarian and cervical cancers (shown for OVCAR3 and HeLa cell lines), while limiting its bioactivity on MUC16-negative Jurkat cells. The gene discussed is MSLN; the disease is cervical carcinoma.