Figure 2 shows the crystal structures of both holo-bLF and human apo-LF. Several years later, another Japanese group assessed the in vivo anti-angiogenic effects of apo-bLF both in the CAM angiogenesis model and in tumor-induced angiogenesis using the dorsal air sac assay [27]. In this study, in vitro anti-angiogenic effects of apo-bLF were also observed in endothelial cell cultures. The gene discussed is LTF; the disease is neoplasm.