The same year 1997 in which milk angiogenin-2 was isolated and characterized as a pro-angiogenic milk protein, a Japanese research group reported that another bovine milk protein, lactoferrin (bLF), and a pepsin-generated peptide of bLF, lactoferricin (bLfcin) were able to inhibit tumor angiogenesis and metastasis in syngenic mice experimental models [18]. Here, LTF is linked to neoplasm.