Despite our previous study showing cyclin E2 was up-regulated through cyclin D1 but not MYC in MCF-7 cells[53], we noted that cyclin E2 expression was reduced following MYC RNAi in 5 of 9 MYC-dependent cell lines, suggesting cell type and genetic context-dependent regulation of cyclin E2 expression in breast cancer cells. The gene discussed is CCND1; the disease is breast cancer.