To elucidate the coronary microvascular response regardless of the presence of coronary lesions or capillary depletion in DCM hearts, we can suggest that chronic LV dyssynchrony following Cx-43 depletion, typical of patients with LBBB and severe contractile dysfunction [53], might affect the myocardial viability [54]. The gene discussed is GJA1; the disease is familial dilated cardiomyopathy.