We examined 19 different serum biomarkers from different pathways implicated in dengue pathogenesis focusing on: endothelial activation and angiogenesis (Ang-1, Ang-2, sTie-2, sTie-1, VEGF, sFlt-1, sFlk-2, sEng, angiopoietin-like 4), inflammation (CRP, IL-10, IL-18BP, IP-10/CXCL10, sICAM-1, CHI3L1), complement activation and coagulation (C5a, Factor D, PF4) and the regulation of lipids (angiopoietin-like 3). This evidence concerns the gene CHI3L1 and dengue disease.