As shown in Figure 4A, the results of western blotting showed that the expression of β-catenin and cyclin-D1 that is β-catenin target molecule was simultaneously down-regulated in tumor tissues of mice treated with hUCMSCs-LV-IL-21 in comparison with the control group, hUCMSCs group and hUCMSCs-LV-Vec group. The gene discussed is CCND1; the disease is neoplasm.