Although the expression of GOLPH3 changed minimally in CRC cells treated with increased doses of 5-FU (Additional file 7: Figure S5), overexpression of GOLPH3 increased the cleaved PARP in both RKO and LoVo cells administrated with 5-FU (Figure 5A and Figure 5C). Here, GOLPH3 is linked to colorectal carcinoma.