GOLPH3 and colorectal carcinoma: However, in contrast with other studies, our results showed that high levels of GOLPH3 expression indicated favourable prognosis in patients who underwent 5-FU-based adjuvant chemotherapy, suggesting that CRC patients with tumors exhibiting high GOLPH3 expression may be more likely to benefit from 5-FU-based adjuvant chemotherapy than those with tumors exhibiting low GOLPH3 expression.