In AML, aberrant DNA methylation has been observed in several of functionally relevant genes, such as p15, p16, p73, E-cadherin, ID4 and RARβ2. It was shown for instance by Hopfer and coauthors [7] that associations between aberrant promoter methylation and DNMT expression predict high-risk MDS for all lineages and during erythropoiesis. This evidence concerns the gene DNMT1 and acute myeloid leukemia.