Nuclear factor-κB (NF-κB) protein levels were enhanced, together with a decrease in protein levels of nuclear factor erythroid-2-related factor-2 (Nrf2) and carnitine palmitoyltransferase 1 (CPT1) in liver and cardiac tissues of high-carbohydrate, high-fat diet-induced metabolic syndrome rats [11]. The gene discussed is NFE2L2; the disease is metabolic syndrome.