We conclude that at least 2 genes in this gene cluster influence risk for AD: TREM2-p.R47H is associated with increased risk for AD (OR = 1.91, CI = 1.85–1.97) and TREML2-p.S144G is associated with reduced risk for AD (OR = 0.91; CI = 0.86–0.97). Here, TREML2 is linked to Alzheimer disease.