Based on the preliminary results of the above two phase II studies, a multi-center, randomized, double-blind, placebo-controlled phase III trial (BO20603) was initiated in 2009 to compare the safety and efficacy of bevacizumab plus rituximab and CHOP (A-R-CHOP) versus R-CHOP in previously untreated CD20+ DLBCL. The gene discussed is DDIT3; the disease is diffuse large B-cell lymphoma.