By contrast, Onalan et al. reported that the PAI-1 4G/4G genotype was related to a lower risk of the development of stable coronary artery disease because of the inhibitory effects of PAI on cellular migration.40 Likewise, some studies suggested that higher plasma levels of PAI were associated with the 4G/4G genotype, which could have been the cause of reduced plaque growth.41,42 There is no study investigating the relationship between CSF and PAI-1 polymorphism in the literature. The gene discussed is SERPINE1; the disease is coronary artery disorder.