CD274 and neoplasm: Optimization of combined radiation and T cell-based therapy can be achieved using a PD-L1 blocking antibody and in animal models, radiation-induced CD8+ T cell immunity could be rescued from the PD-1/PD-L1 inhibitory signaling pathway using anti-PD-L1 led to dramatic increase in the antigen-specific T cell pool in the draining lymph nodes and complete tumor eradication in mice treated with the combination of anti-PD-L1 blockade and radiation therapy [51].