In this study, we first investigated the STMN-1 protein expression in esophageal adenocarcinomas tissue (n = 63) by western blotting analysis, and showed that STMN-1 was highly expressed in 31 (49.21%) of the 63 distal esophageal adenocarcinoma cases (Table 1). This evidence concerns the gene STMN1 and esophageal adenocarcinoma.