This classification is helpful for studying blood B-cell subset alterations in pSS: in peripheral blood, Bm2 (IgD+/CD38 low) and Bm2′ (IgD+/CD38 high) populations include mainly transitional and activated naïve B cells and are increased in pSS patients, whereas eBm5 (IgD-/CD38 low) and Bm5 (IgD-/CD38-) populations are memory B cells, which are less represented in patients with pSS compared to patients with rheumatoid arthritis or normal control subjects [10]. This evidence concerns the gene CD38 and peeling skin syndrome.