BTK and B-cell chronic lymphocytic leukemia: Several novel BTK inhibitors such as GDC-0824, RN-486, CGI-560, CGI-1746, HM-71224, CC-292, ONO-4059, CNX-774, and LFM-A13 are under active preclinical and clinical development for CLL, B cell NHL and autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus.