BDNF and major depressive disorder: For instance, rather than investigating child adversity as one overarching construct, Aguilera and colleagues [66] focused on different types and only found a significant interaction between child sexual abuse and BDNF. Given the acknowledged heterogeneity in major depression [1], Quinn and associates [65] explored the impact of the child adversity-BDNF interaction on different subtypes of the disorder and found a significant effect for non-melancholic depression only.