AFM and Alzheimer disease: One upregulated (IGHM) and one downregulated (afamin) protein were chosen for this comparison, and the reasons were (i) they are two of the most significantly deregulated proteins in our list, with ratios of up to 1.57 for IGHM and down to 0.69 for afamin), (ii) they have not previously been studied in MCI and AD, and (iii) they may provide new insight into the mechanism of disease.