BGLAP and inflammatory bowel disease: In our previous study on chronic inflammatory bone loss in a mouse IBD model [18], we found that the increase in whole body BMD, and bone microstructural parameters induced by Scl-AbI treatment, was associated with a reduction of inflammation-increased TRAPC5b and a restoration of inflammation-depressed osteocalcin serum levels, which corresponds to increasing bone formation and decreasing bone resorption.