In this study, we showed that an antibody to sclerostin (Scl-AbI) can prevent or restore inflammation-induced systemic bone loss in a murine model of rheumatoid arthritis and had no significant effect on inflammation as assessed by the clinical score (paw inflammation, Figure 1B and Figure 5A) or on the disease incidence (in the prophylactic study, Figure 1A). The gene discussed is SOST; the disease is rheumatoid arthritis.