Differences between the Ccl2 and Cx3cr1 double deficient mouse on Crb1rd8(rd8) background (DKOrd8) and the Crb1rd8 mouse in photoreceptor and RPE pathology, as well as ocularA2E contents and immune responses, show that DKOrd8 recapitulates some human AMD-like features in addition to rd8 retinal dystrophy/degeneration. The gene discussed is CCL2; the disease is age-related macular degeneration.