While recently one report stated that mRNA levels of TLR2, TLR6, and TLR7 are decreased in mice fed a high-fat diet (43), other studies provide evidence that TLR1-9 and TLR11-13 are up-regulated in murine adipose tissue following obesity-induction by a high-fat diet (37). This evidence concerns the gene TLR2 and obesity due to melanocortin 4 receptor deficiency.