These morphological abnormalities, the significant accumulation of undegraded GalAAG and the minor alterations in the concentration of seminolipids, previously reported in Twitcher mice by our group, demonstrated the pleiotropic effect of the GALC gene suggesting its importance in the development and function of the male reproductive system and indicating in its deficiency the cause of infertility of the Twitcher males. Here, GALC is linked to Infertility.