It could be speculated that PLP overexpression and the sequestration of PLP and cholesterol into LE/Lys has a qualitative or quantitative impact on exosome secretion from oligodendrocytes, which could relate to the myelin degeneration and the axonopathy observed in PLP1-transgenic animals and PMD patients. Here, PLP1 is linked to Pelizeaus-Merzbacher spectrum disorder.