The other three proteins, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (PIK3CG), v-akt murine thymoma viral oncogene homolog 2 (AKT2) and caspase 9, apoptosis-related cysteine peptidase (CASP9) were all involved in tumorigenesis or cancer progress45, 46, 47. This evidence concerns the gene CASP9 and cancer.