The phosphorylation of Ser396/Ser404 in neuroblastoma cells treated with lipid peroxidising agents can be blocked by inhibitors of either GSK3β or the stress-activated kinase p38, but not by cyclin-dependent kinase-5, supporting the view that phosphorylation of this epitope could be part of a co-ordinated neuronal stress response. Here, GSK3B is linked to neuroblastoma.