MAPT and Alzheimer disease: Following our studies of Tau phosphorylation in AD post-mortem brain (Hanger et al., 1998; Hanger et al., 2007), we were interested to determine whether the Drosophila photoreceptor model could be used to assess the roles of human kinases in mediating neurodegeneration in vivo and to identify particular phosphorylation events on Tau that are important for toxicity.