Four genes (HER4, PIK3CA, PIK3R1 and VEGFD) were not expressed; five genes (AKT2, AKT3, HER2, PIK3R2 and VEGFC) were not differentially expressed; five genes (AKT1, HER3, HIF1A, PIR and VEGFB) were slightly down-regulated (≤ 1.5 FC, P-value ≤ 0.05); HER1/EGFR was more strongly down-regulated (≥ 1.5 FC, P-value ≤ 0.05), and VEGFA was up-regulated (≥ 1.5 FC, P-value ≤ 0.05) in SRSF2-over-expressing H358 lung cancer cells in comparison to H358 control cells. The gene discussed is PIK3CA; the disease is lung cancer.