IL1RN and Sepsis: Five SNPs in IL-1 genes have been most frequently studied in relation to sepsis risk: one SNP at promoter position −889 in the IL-1A gene, two SNPs at promoter position −511 and −31 and one SNP in exon 5 at position +3954 of the IL-1B gene and a variable number of tandem repeats (VNTR) of 86-bp sequence in intron 2 of IL-1RN gene, 5 alleles of which have been reported (1 to 5) corresponding to 4, 2, 5, 3 and 6 copies of 86-bp sequence, respectively.