Given the tumor-suppressor role of IGFBP7 in CRC cell lines [30] and the high expression in the invasive front of CRC tumors (unpublished results), the present findings showed that SW620-S induced IGFBP7 expression in fibroblasts, following the incubation of fibroblasts in the presence of SW620-S for various lengths of time. The gene discussed is IGFBP7; the disease is colorectal carcinoma.