Aberrations in HNF4α functionality are linked to development of severe cirrhotic livers, alcoholic liver disease, tumor necrosis factor-α-induced hepatotoxicity, and hepatocellular carcinoma where HNF4α has antiproliferative effect and serves as a tumor suppressor [4], [5], [7]–[9]. The gene discussed is HNF4A; the disease is neoplasm.