DCC and colorectal cancer: Through genetic analysis of a well-characterized AVM axon ventral guidance event and a less characterized AVM synapse formation event, it was shown that lin-4 functions as a potent and specific negative regulator of netrin signaling in AVM neuronal connectivity by targeting the LIN-14 transcription factor to control the availability of the netrin receptor UNC-40/DCC (Deleted in Colorectal Cancer; Figure 1B; Zou et al., 2012).