The role of paracrine factors such as angiogenic peptide basic fibroblast growth factor (bFGF) have been illustrated in different tumors including leukemia [30,31], and solid tumors such as IL-6 (interleukin 6) in melanoma [32] or jagged 1 in colon cancer [33]. Here, FGF2 is linked to malignant colon neoplasm.