Here, we were able to confirm the previous data of our group (23,24) that revealed that prorenin mediates pro-proliferative effects via the (P)RR-PLZF axis (Fig. 7A) which is also consistent with a microarray analysis linking (pro)renin stimulation with a gene signature associated with cardiac hypertrophy (20). Here, ZBTB16 is linked to cardiac hypertrophy.