Recent studies have demonstrated that TLR3 is involved in the pathogenesis of virus infection and autoimmune disorders, especially RA, in which RA synovial fibroblasts (RASFs) from early-stage patients highly express TLR3 and react with its ligand in vitro, suggesting that this pathway is activated early in the disease process[6,7]. Here, TLR3 is linked to rheumatoid arthritis.