In this study, there was a trend toward an increase in the level of G-CSF and GM-CSF after the administration of glimepiride for 24 weeks, suggesting that glimepiride has effects on angiogenesis, which is a pivotal mechanism that influences several physiological and pathological processes, including wound healing, because GM-CSF is known to induce bone marrow precursors to protect against the development of diabetes and to induce wound healing in diabetic mice [32-34]. The gene discussed is CSF2; the disease is diabetes mellitus.